Phase 2b Study of EVO756 in Adults With Moderate to Severe Chronic Spontaneous Urticaria (CSU)

Completed · Phase 2 · Has a placebo group

Conditions studied: Chronic Spontaneous Urticaria

In brief

This study will evaluate the efficacy and safety of different doses of EVO756 in adults with moderate to severe chronic spontaneous urticaria (CSU).

Key facts

Study ID

NCT06873516

Run by

Evommune, Inc.

People needed

182

Starts

2025-03-20

Expected to finish

2026-06-05

Last updated by the study team

2026-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed CSU diagnosis for at least 3 months with an inadequate response to H1-antihistamines.
• Subjects who are taking H1-antihistamines must be on a stable regimen 4 weeks prior to Day 1 and while on study.
• Urticaria Activity Score (UAS7) equal to or greater than 16 at Day 1. UAS entries must be completed for a minimum of 4 out of the 7 days prior to Day 1.

You may not qualify if…

• Any clinically significant abnormality in laboratory evaluations, physical examinations, vital signs, or ECG at Screening, according to the Investigator's discretion.
• Use of certain medications.
• History of diseases with urticaria or angioedema symptoms, other than CSU and symptomatic dermographism.
• Significant medical history other than CSU, or any other condition which might interfere with the evaluation of CSU.

Where it is running

• Velocity Clinical Research, Mobile — Mobile, Alabama, United States
• Center for Dermatology Clinical Research — Fremont, California, United States
• Antelope Valley Clinical Trials — Lancaster, California, United States
• Northridge Clinical Trials — Northridge, California, United States
• NorthBay Clinical Research — Santa Rosa, California, United States
• Integrated Research of Inland — Upland, California, United States
• FOMAT Medical Research — Ventura, California, United States
• AMR Fort Myers — Fort Myers, Florida, United States
• Advanced Clinical Research Institute — Tampa, Florida, United States
• Sneeze, Wheeze & Itch Associates LLC — Normal, Illinois, United States
• The Indiana Clinical Trials Center — Plainfield, Indiana, United States
• The Iowa Clinic — West Des Moines, Iowa, United States
• Hutchinson Clinic — Hutchinson, Kansas, United States
• Bluegrass Allergy Care — Lexington, Kentucky, United States
• Delricht Research Louisville — Louisville, Kentucky, United States
• Delricht Research Louisiana — Baton Rouge, Louisiana, United States
• Velocity Clinical Research, Lafayette — Lafayette, Louisiana, United States
• Delricht Research — New Orleans, Louisiana, United States
• Johns Hopkins Bayview Medical Center — Baltimore, Maryland, United States
• Boston Specialists — Boston, Massachusetts, United States
• MI Skin Innovations — Northville, Michigan, United States
• DelRicht Research - Town Center Dermatology — Wildwood, Missouri, United States
• Vitality Clinical Trials — Woodbury, New York, United States
• Allergy Partners Clinical Research — Asheville, North Carolina, United States
• Cahaba Dermatology Skin Health Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.