Exploring Water-free Sodium Storage

Recruiting now · Not applicable

Conditions studied: Peritoneal Dialysis, Heart Failure

In brief

The overarching goal of this proposal is to definitively establish if acute water free Na storage and release occurs, if the amount stored/released is of a quantity that is physiologically relevant, and if the location is intracellular vs. extracellular.

Key facts

Study ID

NCT06872645

Run by

Yale University

People needed

10

Starts

2025-10-03

Expected to finish

2028-06-30

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ESRD Patients actively undergoing PD with a reliably functioning PD catheter
• Systolic blood pressure > 130 mmHg
• Serum sodium >135 mmol/L
• daily urine output < 400ml
• stable PD prescription for at least 2 months without requirement of 4.25% glucose PD solution
• PD vintage of at least 6 months
• Euvolemic as defined by the patient at their dry weight and free of any signs or symptoms of volume overload, per referring nephrologist

You may not qualify if…

• Poorly controlled diabetes with hemoglobin A1C>9%
• 1 or more episodes of peritonitis in the previous 6 months or active infection of the peritoneal dialysis catheter
• Anemia with hemoglobin <8g/dL
• Inability to give written informed consent or follow study protocol.
• Urinary incontinence
• Body weight < 60kg
• gastrointestinal disease that causes diarrhea or expectation of sodium losses in stool.
• use of amiodarone in the last 6 months (which will interfere with tissue iodine ascertainment).

Where it is running

• Yale University — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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