Pre-malignant States to Hematologic Malignancies in Firefighters

Recruiting now

Conditions studied: Clonal Hematopoiesis of Indeterminate Potential, Monoclonal Gammopathy, Non Hodgkin Lymphoma, Leukemia, Multiple Myeloma, Plasma Cell Disorder

In brief

The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.

Key facts

Study ID

NCT06870760

Run by

Wake Forest University Health Sciences

People needed

300

Starts

2026-06-23

Expected to finish

2027-04-01

Last updated by the study team

2026-07-13

Who can join

Age: 40 and older, up to 49. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Written informed consent and HIPAA authorization for release of personal health information.
• Age ≥ 40-49 years at the time of consent (self-reported)
• Ability of the participant to understand and comply with study procedures for the entire length of the study
• Currently employed by Charlotte Fire Department (CFD) with at least 5 years on-the -job experience (self-reported)

You may not qualify if…

• Anyone with a current diagnosis of a hematologic malignancy will be excluded.

Where it is running

• Levine Cancer Institute — Charlotte, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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