Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis
Starting soon · Not applicable
Conditions studied: Clinical High Risk for Psychosis (CHR)
In brief
The main objective is to evaluate the efficacy of a group-based mindfulness therapy programme in reducing distress associated with symptoms of UHR (Ultra High Risk) or FEP (first psychotic episode) compared with usual treatment. The secondary objectives were to study the efficacy of a group-based mindfulness intervention: on the reduction of psychotic symptoms; on the maintenance over time (6 months of follow-up) of the efficacy of the intervention on the distress associated with the symptoms of the UHR or PEP state; and on various dimensions associated with care: cognitive functions, anxiety, quality of life.
Key facts
- Study ID
- NCT06870305
- Run by
- Centre Psychothérapique de Nancy
- People needed
- 270
- Starts
- 2029-04-01
- Expected to finish
- 2029-12-01
- Last updated by the study team
- 2026-03-25
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- People aged between 18 and 30 validating the criteria for UHR or PEP status on the CAARMS scale and having a social functional impact (SOFAS score below 50 or a reduction of more than 30% in the score)
You may not qualify if…
- Previous episode of schizophrenic disorder, schizoaffective disorder or bipolar disorder
- Previous antipsychotic treatment for more than 12 months
- Organic mental disorder or intellectual disability
- Serious suicidal/homicidal risk (but admissible if this risk has been resolved)
- Insufficient French language skills
- Adult incapable of giving consent and not under legal protection
- Protection measure (guardianship/curatorship/court supervision) or under court supervision
- Person deprived of liberty by judicial or administrative decision (including forced hospitalisation)
- Persons in a life-threatening emergency
- Not affiliated to a social security regime
Where it is running
- Centre Hospitalier Universitaire (CHU) de Brest — Brest, France
- Centre Psychothérapique de Nancy — Laxou, France
Full record on ClinicalTrials.gov
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