Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors

Recruiting now

Conditions studied: Insomnia, Cardiorespiratory Fitness, Metabolic Disease

In brief

Insomnia is a highly prevalent sleep disorder worldwide, with an increasing incidence in athletes, older adults, university students, and individuals with metabolic syndrome. This disorder has been associated with metabolic dysfunction, cardiovascular diseases, and genetic instability. Recent evidence suggests that insomnia negatively impacts cardiorespiratory fitness, insulin sensitivity, and overall health through mechanisms involving neuroendocrine dysregulation, oxidative stress, and alterations in energy metabolism. However, the specific biological and environmental factors that contribute to its prevalence and health consequences remain poorly understood, particularly across different populations. Understanding these associations is crucial for developing effective prevention and intervention strategies to mitigate the long-term impact of insomnia. Therefore, this study aims to analyze the impact of insomnia on body composition, cardiorespiratory fitness, metabolic flexibility, and DNA integrity, across populations with high prevalence of insomnia, including athletes, older adults, university students, and individuals with metabolic syndrome. This study will also investigate which biological and lifestyle behaviors contribute to insomnia and its health consequences. By doing so, this work will provide critical insights into the physiological and molecular mechanisms that link insomnia with metabolic and cardiovascular dysfunction, contributing to the development of targeted interventions for at-risk populations

Key facts

Study ID

NCT06869486

Run by

Universidad Autonoma de Baja California

People needed

300

Starts

2024-10-01

Expected to finish

2026-12-31

Last updated by the study team

2025-03-11

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Each population group will meet the following inclusion criteria:
• Healthy Individuals (18-35 years old, men and women)
• Waist circumference: <90 cm (men), <80 cm (women)
• Fasting glucose: 70-110 mg/dL
• Blood pressure: <120/80 mmHg
• Triglycerides: <150 mg/dL
• HDL-C: >40 mg/dL (men), >50 mg/dL (women)
• Physical activity level: 600-1500 MET-min/week
• Athletes (18-35 years old, men and women)
• Engaged in structured sports training with a physical activity level >1500 MET-min/week
• Older Adults (65-75 years old, men and women)
• Free of cognitive or mental health disorders. No specific cardiometabolic or body composition criteria due to the study's exploratory nature.
• University Students (18-35 years old, men and women)
• No specific cardiometabolic or body composition criteria due to the study's exploratory nature.
• Individuals with Metabolic Syndrome (18-35 years old, men and women)
• Waist circumference: >90 cm (men), >80 cm (women)
• Fasting glucose: >110 mg/dL
• Blood pressure: >130/80 mmHg
• Triglycerides: >150 mg/dL
• HDL-C: <40 mg/dL (men), <50 mg/dL (women)
• Physical activity level: <600 MET-min/week

You may not qualify if…

• Individuals with respiratory diseases or musculoskeletal injuries that prevent exercise, as determined by a clinical history review, a physical activity readiness questionnaire (PART-Q+), and pulmonary function tests (spirometry).
• Individuals with rotating or night-shift work schedules (e.g., emergency personnel, security guards), as circadian rhythm disruptions significantly impact sleep quality
• Women diagnosed with polycystic ovary syndrome (PCOS) or showing high testosterone levels with a history of oligomenorrhea, as these conditions may influence metabolic and hormonal markers. However, women with menstrual irregularities related to premenstrual syndrome (PMS) or dysmenorrhea will not be excluded, given the established link between sleep disorders and menstrual cycle variations
• This study does not involve chronic dietary or exercise interventions, nor does it require long-term participant follow-up, so no additional exclusion criteria apply

Where it is running

• Laboratorio de Fisiologia Aplicada al Ejercicio — Ensenada, Estado de Baja California, Mexico (enrolling)

Full record on ClinicalTrials.gov

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