Rheological Functions of Erythrocyte in ESRD

Recruiting now

Conditions studied: End-stage Renal Disease (ESRD)

In brief

End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction

Key facts

Study ID

NCT06868888

Run by

Chang Gung Memorial Hospital

People needed

40

Starts

2022-08-24

Expected to finish

2025-03-26

Last updated by the study team

2025-03-11

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Receiving hemodialysis and medication at least for 6 weeks
• Kt/V score > 1.2

You may not qualify if…

• Under 20 years-old
• Hyperkalemia occurs within 3 month
• Having orthopedic or muscular diseases
• Other concerned medical, psychological or physiological diseases
• Pregnancy
• Other exercise contraindications

Where it is running

• Chang Gung University — Taoyuan, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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