A Study of LM-168 as a Single Agent or in Combination With Toripalimab in Subjects With Advanced Solid Tumours

Recruiting now · Phase 1/Phase 2

Conditions studied: Advanced Solid Tumours

In brief

For phase I ,this study is to assess the safety and tolerability, obtain the recommended phase 2 dose (RP2D) and/or Maximum Tolerated Dose (MTD) for LM-168 as a single agent or in combination with toripalimab in subjects with advanced solid tumours. For phase II ,this study is to assess the preliminary anti-tumour activity of LM-168 as a single agent or in combination with toripalimab measured by objective response rate (ORR) in subjects with advanced solid tumours.

Key facts

Study ID

NCT06868199

Run by

LaNova Medicines Limited

People needed

87

Starts

2025-05-06

Expected to finish

2028-02-01

Last updated by the study team

2025-09-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects who are willing to participate in the study and sign the informed consent form (ICF) prior to any procedure.
• Aged ≥18 years old (including boundary values) , male or female.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
• Life expectancy ≥ 3 months.
• In dose escalation stage, subjects must have histological or cytological confirmation of recurrent or refractory advanced solid tumours, and have progressed on standard therapy, or are intolerable for available standard therapy, or there is no available standard therapy.
• In dose expansion stage, subjects must have histological or cytological confirmation of selected advanced solid tumors.
• Pre-treatment archived tumour tissue or on-treatment tumour biopsy could be provided for biomarker analysis optionally.
• At least one measurable disease.
• Subjects must show appropriate organ and marrow function in laboratory examinations within 7 days prior to the first dose.
• Subjects who are able to communicate well with investigators and understand and adhere to the requirements of this study.

You may not qualify if…

• Participate in any other clinical trial within 28 days prior to 1st dosing of LM-168.
• Having received prior anti-CTLA-4 or any other immunotherapy or immune-oncology (IO) agent within 28 days of commencing treatment with LM-168 or experienced a toxicity that led to permanent discontinuation of prior immunotherapy.
• Subjects who have received the anti-tumor treatments within the specified time periods prior to the first dosing of LM-168.
• Any adverse event from prior anti-tumour therapy has not yet recovered to ≤ grade 1 of CTCAE v5.0.
• Subjects with uncontrolled tumour-related pain.
• Subjects with known central nervous system (CNS) or meningeal metastasis.
• Subjects who have uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures.
• Subjects with esophageal or gastric varices requiring immediate intervention, or those with a history of variceal bleeding.
• Hepatic encephalopathy, hepatorenal syndrome, Child-Pugh class B or more severe liver cirrhosis.
• Tumor invasion of surrounding vital organs or a risk of developing esophagotracheal fistula or esophagopleural fistula.
• Patients with a history of active or previously confirmed inflammatory bowel disease.
• Subjects who experienced grade 3 or higher hypersensitivity to the treatment that contains monoclonal antibody.
• Subjects who previously experienced grade ≥ 3 immune-related adverse events during immunotherapy, as well as subjects who discontinued prior immunotherapy due to severe or life-threatening immune-related adverse events.
• Subjects who take systemic corticosteroids (> 10 mg daily prednisone equivalents) or other systemic immunosuppressive medications within 2 weeks prior to the first dosing of LM-168.
• Subjects with the known history of autoimmune disease.
• Subjects with the history of idiopathic pulmonary fibrosis, organizing pneumonia , drug-induced pneumonitis, idiopathic pneumonitis, interstitial lung disease, severe radiation pneumonitis or evidence of active pneumonitis on screening chest CT scan.
• Use of any live attenuated vaccines within 28 days prior to 1st dosing of LM-168.
• Current or recent use of aspirin (> 325 mg/day) or treatment with dipyramidole, ticlopidine, clopidogrel, and cilostazol.
• Current unstable of full-dose oral or parenteral anticoagulants or thrombolytic agents for > 2 weeks prior to the first dose of LM-168.
• Subjects who received major surgery or interventional treatment within 28 days prior to 1st dosing of LM-168 (excluding tumour biopsy, puncture, etc.).
• Subjects who have severe cardiovascular disease.
• Subjects who have uncontrolled or severe illness.
• Subjects who have a history of immunodeficiency disease.
• HIV infection, active infection including tuberculosis, HBV and HCV infection.
• Subjects with a history of other malignancies within 5 years prior to the first administration of the study drug.

Where it is running

• Macquarie University — Ryde, New South Wales, Australia (enrolling)
• MUPharm Pty Limited trading as Macquarie University Hospital Parmarcy — Ryde, New South Wales, Australia (enrolling)
• Cancer Care Wollongong Pty Limited — Wollongong, New South Wales, Australia (enrolling)
• Bayview Health-Investigational Drug Services — Perth, Western Australia, Australia (enrolling)
• One Clinical Reasearch — Perth, Western Australia, Australia (enrolling)
• Beijing Cancer Hospital — Beijing, Beijing Municipality, China

Full record on ClinicalTrials.gov

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