The Effect of Cardiac Rehabilitation on Oxidative DNA Damage and Inflammation in Patients With Coronary Artery Disease
Recruiting now · Not applicable
Conditions studied: Coronary Arterial Disease (CAD)
In brief
The objective of this study was to determine the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an indicator of oxidative stress, and to demonstrate oxidative DNA damage in cardiac rehabilitation treatment in patients with coronary artery disease. Additionally, proinflammatory cytokines TNFα, IL-1β, and IL-6 levels were measured to evaluate the significance of cardiac rehabilitation treatment in patients with coronary artery disease and to assess the correlation between cytokine levels and 8-OHdG levels.
Key facts
- Study ID
- NCT06867926
- Run by
- TC Erciyes University
- People needed
- 70
- Starts
- 2025-05-15
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-05-02
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Inclusion Criteria for Patient Volunteers
- Patients aged 18-65 years with a diagnosis of coronary artery disease and no contraindications to cardiac rehabilitation and exercise testing
- Patients who will undergo cardiopulmonary exercise testing before cardiac rehabilitation
- Patients whose cognitive status is sufficient to complete the study and who can cooperate
- Inclusion Criteria for Healthy Volunteers
- 18 years of age or older
- Not having a chronic disease (such as uncontrolled diabetes mellitus, hypertension, heart and kidney failure)
- Not taking regular medication
You may not qualify if…
- Exclusion Criteria for Patient Volunteers
- Having heart failure
- Unstable Angina Pectoris
- Complex ventricular arrhythmia
- Having a pacemaker
- Having orthopedic or neurological diseases that prevent exercise
- Having kidney-liver disease
- Exercise is contraindicated
- History of inflammatory diseases
- Having a history of cancer-immunologic disease
- Exclusion Criteria for Healthy Volunteers
- Having a history of chronic diseases such as diabetes mellitus, hypertension, heart and kidney failure
- Being on regular medication for the last 6 months
- being under 18 years of age
Where it is running
- Erciyes University Faculty of Medicine — Kayseri, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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