A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: RSV Infection

In brief

This study aims to check how safe and well-tolerated a second dose of RSVpreF is when given during later pregnancies, and to see how long the immunity lasts from a single dose given during a previous pregnancy by examining the blood of nonpregnant participants who had the vaccine before.

Key facts

Study ID

NCT06866405

Run by

Pfizer

People needed

550

Starts

2025-04-16

Expected to finish

2028-02-24

Last updated by the study team

2026-07-09

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

Where it is running

• Children's of Alabama — Birmingham, Alabama, United States (enrolling)
• University of Alabama at Birmingham - School of Medicine — Birmingham, Alabama, United States (enrolling)
• University of Alabama at Birmingham Women & Infants Center — Birmingham, Alabama, United States (enrolling)
• USA Health Children's and Women's Hospital — Mobile, Alabama, United States (enrolling)
• USA Health Strada Patient Care Center — Mobile, Alabama, United States (enrolling)
• Ronald Reagan UCLA Medical Center — Los Angeles, California, United States (enrolling)
• Ronald Reagan UCLA Medical Center (inpatient hospital) — Los Angeles, California, United States (enrolling)
• Ronald Reagan UCLA Medical Center — Los Angeles, California, United States (enrolling)
• UCLA (outpatient clinic) — Los Angeles, California, United States (enrolling)
• UCLA Clinical and Translational Research Center (research clinic) — Los Angeles, California, United States (enrolling)
• UCLA — Los Angeles, California, United States (enrolling)
• Lucile Packard Children's Hospital-Labor and Delivery Unit — Palo Alto, California, United States (enrolling)
• Stanford Obstetrics Clinic — Palo Alto, California, United States (enrolling)
• Stanford University Medical Center — Palo Alto, California, United States (enrolling)
• Stanford University — Palo Alto, California, United States (enrolling)
• Anschutz Health Sciences Building (AHSB) — Aurora, Colorado, United States (enrolling)
• Children's Hospital Colorado — Aurora, Colorado, United States (enrolling)
• CU Research Pharmacy — Aurora, Colorado, United States (enrolling)
• University of Colorado AO1 UCH — Aurora, Colorado, United States (enrolling)
• University of Colorado Hospital Inpatient Pavilion — Aurora, Colorado, United States (enrolling)
• University of Colorado Hospital Outpatient Pavilion — Aurora, Colorado, United States (enrolling)
• University of Colorado Research II Building — Aurora, Colorado, United States (enrolling)
• Citadelle Clinical Research — North Miami Beach, Florida, United States (enrolling)
• Emerald Coast OBGYN Clinical Research — Panama City, Florida, United States (enrolling)
• Center for Research in Women's Health — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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