Enhancing Emotion Regulation Through Functional Near-infrared Spectroscopy (fNIRS)-Informed Real-time Neurofeedback

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Neurofeedback, Emotion Regulation, Stress

In brief

The present study aims to employ real-time functional near-infrared spectroscopy (fNIRS) neurofeedback training in combination with cognitive reappraisal strategies for regulating negative emotions in healthy individuals. Participants will complete: * Cognitive reappraisal training with either real neurofeedback or sham feedback. * Questionnaires at pre- and post- training timepoints * A cold-pressor test at the end of the training It is hypothesized that combining real-time fNIRS neurofeedback and cognitive reappraisal training will enhance emotion regulation in healthy individuals: 1. Increased neural activity in the prefrontal cortex (PFC) region of the brain will be significantly higher in the real neurofeedback group after training compared to the sham feedback group. 2. Real-time fNIRS-guided upregulation of the PFC will enhance emotion regulation during exposure to negative stimuli/scenes across the training runs. 3. The effects of fNIRS neurofeedback training will extend to influence emotion regulation in a cold-pressor test administered post-training, wherein individuals in the real neurofeedback group demonstrate better regulation of stress and pain induced by the task.

Key facts

Study ID

NCT06866028

Run by

University of Electronic Science and Technology of China

People needed

50

Starts

2024-08-08

Expected to finish

2026-08-07

Last updated by the study team

2025-03-27

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal/corrected-to-normal vision
• Right-handed
• Below the cut-off for clinically-significant levels of depression (below 29) indicated by the Beck Depression Inventory (BDI-II; Beck et al., 1996)

You may not qualify if…

• Current/history of mental health conditions
• Current/history of chronic pain
• The following conditions: Cardiovascular disorder, Raynaud's phenomenon, fainting, seizure, wounds on the hand/arm
• Frequent use of alcohol/nicotine

Where it is running

• The Hong Kong Jockey Club Building For Interdisciplinary Research, 5 Sassoon Rd, Sandy Bay — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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