4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Running, not enrolling · Phase 3

Conditions studied: Macular Neovascularization Secondary to Age-Related Macular Degeneration

In brief

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial in Adults with Macular Neovascularization Secondary to Age-Related Macular Degeneration

Key facts

Study ID

NCT06864988

Run by

4D Molecular Therapeutics

People needed

480

Starts

2025-03-03

Expected to finish

2028-06-01

Last updated by the study team

2026-06-01

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥50 years of age at time of consent
• Treatment naïve MNV secondary to nAMD in the study eye
• Active subfoveal MNV or juxtafoveal/ extrafoveal MNV with a subfoveal component (where activity is defined as evidence of SRF, IRF, subretinal hyperreflective material, or leakage) identified by fluorescein angiography (FA) or spectral domain optical coherence tomography (SD-OCT), in the study eye, at the Screening Visit confirmed by the Reading Center
• Demonstrated clinical response to aflibercept and functional stability in the study eye as confirmed by the Reading Center
• BCVA between 25 and 78 ETDRS letters, inclusive (20/320-20/32 Snellen equivalent) in the study eye at the Screening Visit
• CST less than or equal to 500 microns in the study eye at screening visit, confirmed by the central reading center

You may not qualify if…

• Ocular Conditions:
• MNV due to causes other than nAMD in either eye (Fibrosis, atrophy, or subretinal hemorrhage in the foveal central subfield (1 mm diameter))
• History of retinal detachment in the study eye
• History of or presence of active inflammation in either eye
• Glaucoma or intraocular hypertension requiring more than 2 topical medications for control
• Systemic Conditions and Considerations:
• Major illness or major surgical procedure in the 28 days prior to the Screening Visit
• Uncontrolled blood pressure
• Acute coronary syndrome, myocardial infarction or coronary artery revascularization, cerebrovascular accident, transient ischemic attack within 6 months of the Screening Visit
• History of autoimmune condition that may predispose to the development of uveitis

Where it is running

• Retinal Research Institute, LLC — Scottsdale, Arizona, United States
• Retina Partners of Northwest Arkansas — Springdale, Arkansas, United States
• California Retina Consultants — Bakersfield, California, United States
• Retina Vitreous Associates Medical Group — Beverly Hills, California, United States
• The Retina Partners — Encino, California, United States
• Retina Associates of Southern California — Huntington Beach, California, United States
• Northern California Retina Vitreous Associates — Mountain View, California, United States
• Retina Consultants of San Diego — Poway, California, United States
• Kaiser Permanente-Riverside Medical Center — Riverside, California, United States
• Retinal Consultants Medical Group Inc — Sacramento, California, United States
• Retinal Consultants Medical Group Inc — Sacramento, California, United States
• Orange County Retina Medical Group — Santa Ana, California, United States
• California Retina Consultants - Santa Barbara — Santa Barbara, California, United States
• Bay Area Retina Associates — Walnut Creek, California, United States
• University of Colorado, Denver — Aurora, Colorado, United States
• Retina Consultants of Southern Colorado — Colorado Springs, Colorado, United States
• RSC Research, LLC — Denver, Colorado, United States
• Connecticut Eye Consultants — Danbury, Connecticut, United States
• Retina Group of Florida — Fort Lauderdale, Florida, United States
• Vitreo Retinal Associates — Gainesville, Florida, United States
• Florida Retina Institute - Jacksonville — Jacksonville, Florida, United States
• Florida Retina Consultants — Lakeland, Florida, United States
• Florida Retina Institute — Orlando, Florida, United States
• Retina Specialty Institute — Pensacola, Florida, United States
• Barnet Dulaney Perkins Eye Center — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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