A Study of CD8+ T Cell Imaging During Treatment in People With Non-Small Cell Lung Cancer

Recruiting now · Phase 1

Conditions studied: Lung Cancer, Non Small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer

In brief

The purpose of this study to learn whether PET/CT (positron emission tomography/computed tomography) scans using an imaging agent (radiotracer) called zirconium Zr 89 crefmirlimab berdoxam is a safe and effective way to identify CD8+ T cells

Key facts

Study ID

NCT06863233

Run by

Memorial Sloan Kettering Cancer Center

People needed

5

Starts

2025-03-03

Expected to finish

2028-03-03

Last updated by the study team

2025-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be 18 years of age or older at the time of signing the informed consent.
• Patient has a histologically confirmed diagnosis of metastatic non-small cell lung cancer
• Patient is enrolled in the engineered TIL cell therapy protocol OBX115-23-01, but has not received the treatment yet.
• Men and women of child-producing potential, use of effective double barrier contraceptive methods during the study, up to 30 days after the last administration of the investigational product.
• Patient or legally authorized representative provided signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
• Patient or legally authorized representative provided written authorization for use and disclosure of protected health information.

You may not qualify if…

• Pregnant or breastfeeding women
• Patients with a history of splenectomy or significant splenic dysfunction (e.g., as evidenced by splenomegaly or a history of recurrent infections due to impaired immune function)

Where it is running

• Memorial Sloan Kettering at Basking Ridge (Consent Only) — Basking Ridge, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Monmouth (Consent Only) — Middletown, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Bergen (Consent Only) — Montvale, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent only) — Commack, New York, United States (enrolling)
• Memorial Sloan Kettering Westchester (Consent only) — Harrison, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center (All protocol activities) — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center @ Nassau (Consent only) — Uniondale, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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