COCONUT Study Concomitant PVI and LAAC

Recruiting now

Conditions studied: Atrial Fibrillation (AF)

In brief

In patients with non-valvular AF, at high stroke risk, and who are ineligible for long-term oral anticoagulation LAAC could be an alternative to anticoagulation and safety and efficacy has been shown in several studies and registries.8 While PVI and LAAC are both conducted in the left atrium and share the same access route, a combined concomitant approach might be beneficial for patients but is not conventionally practiced. Due to significantly shorter procedures times and high safety profile PFA based catheter ablation may be advantageous for the combined approach of PVI and LAAC. We are performing a word-wide, retrospective, multicenter registry study focusing on patients with concomitant Farapulse PFA based PVI and LAAC (WATCHMAN Flx, Boston Scientific). To evaluate safety, efficacy and efficiency in a multicenter study the COCONUT study was conducted.

Key facts

Study ID

NCT06861673

Run by

Asklepios proresearch

People needed

60

Starts

2025-03-01

Expected to finish

2026-12-01

Last updated by the study team

2026-03-19

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Indicatio for PVI and LAAC

You may not qualify if…

• Not eligible for any of the procedures PVI and LAAC

Where it is running

• Asklepios Klinik Altona — Hamburg, Free and Hanseatic City of Hamburg, Germany (enrolling)

Full record on ClinicalTrials.gov

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