STRucturation of Transcript Analysis of Genes Involved in Hereditary Cancers

Recruiting now

Conditions studied: Cancer

In brief

Molecular diagnosis using high throughput sequencing has become an essential part of oncogenetic care, making it possible to identify people at risk, to guide surveillance, and to direct preventive surgery and treatment. The quality of this 'precision' care depends on the quality of the interpretation of the genomic variants identified. To be usable in oncogenetics, a genomic variant must be correctly interpreted: pathogenic, benign or of uncertain significance (VSI). The impact of these DNA variants (VSI) on RNA is particularly important for interpretation. Today, due to a lack of resources, joint and systematic DNA/RNA analysis is never carried out. This has inevitably meant that a number of situations of interest have been overlooked. It is now important to go a step further and organise a visible and reliable circuit, allowing routine access to these studies for patients.

Key facts

Study ID

NCT06861621

Run by

University Hospital, Rouen

People needed

1000

Starts

2023-09-01

Expected to finish

2025-04-01

Last updated by the study team

2025-03-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Over 18 years of age
• Patients seen in oncogenetic consultations and who have given their informed consent for genetic analysis in the context of a major predisposition to breast, ovarian or digestive cancer.
• Person who has read and understood the information note and does not object to taking part in the study
• Membership of a social security scheme

You may not qualify if…

• Minors
• Persons deprived of their liberty or adults under guardianship or incapable of giving their consent
• Failure to obtain informed consent

Where it is running

• Service Oncogénétique Centre François Baclesse — Caen, France (enrolling)
• Clinique de génétique médicale Guy Fontaine de l'hopital de Flandre CHRU de Lille — Lille, France (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.