Precision Antibiotic Dosing for Appendectomy

Recruiting now · Phase 1

Conditions studied: Appendicitis (Diagnosis)

In brief

This research is studying a drug called cefoxitin already approved by the Food and Drug Administration (FDA) to reduce the risk of infection after surgery to remove an appendix. Researchers are studying a large group of people to continue to learn how best to dose antibiotics. This research will compare the current standard treatment which is a single dose prior to surgery to a new method that includes adding another dose of cefoxitin within 30 minutes of starting the surgery. This study will measure cefoxitin concentrations in blood, fat, and appendix tissue samples to compare the standard dosing method to our new method. This information will help us figure out the right dose of this drug to prevent infection after surgery to remove an appendix.

Key facts

Study ID

NCT06860802

Run by

University of Michigan

People needed

46

Starts

2025-02-28

Expected to finish

2026-09-30

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of acute appendicitis and plan to undergo appendectomy at the University of Michigan

You may not qualify if…

• Prisoners
• Patients that are pregnant
• Patients with perforation or abscess on CT Scan

Where it is running

• Michigan Medicine — Ann Arbor, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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