Safety of Short-course of NSAIDs in Pediatric Patients With CKD

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Chronic Kidney Disease, Pediatric Urology

In brief

The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This is currently in the process of developing multi institution collaboration within a Pediatric Urology population, intended to inform future work in a larger patient population.

Key facts

Study ID

NCT06860711

Run by

University of Colorado, Denver

People needed

164

Starts

2025-07-22

Expected to finish

2028-12-01

Last updated by the study team

2026-06-08

Who can join

Age: 2 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients over 18 months of age
• diagnosis of CKD stages 2-3a, confirmed by CKiD U25 eGFR calculator based on cystatin C laboratory testing within 6 months of surgery
• Patient is scheduled to undergo a urologic surgery requiring admission or overnight stay in the hospital

You may not qualify if…

• Diagnosis of CKD stage 1 or 4-5
• Past medical history of renal transplant
• Past medical history of nasal polyp
• Procedure for oncologic indications or on chemotherapy
• Pregnant patient
• True allergy to NSAIDs

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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