Remote Ischemic Conditioning and Spinal Reflex Modulation

Enrolling by invitation · Not applicable · Has a placebo group

Conditions studied: Healthy Young Adults

In brief

Remote ischemic conditioning (RIC) is a clinically feasible method that protects distant organs from severe injury through brief, sub lethal periods of ischemia followed by re-perfusion. Recent studies suggest that RIC, combined with training, improves muscle strength and balance in healthy adults and post-stroke survivors. While the underlying mechanisms are not fully understood, RIC's neuroprotective effects - such as promoting angiogenesis, neurogenesis, and modulating glutamate and GABA synthesis - overlap with neuroplasticity processes. Evidence indicates that neuroplasticity from exercise training occurs not only in the cerebral cortex but also within the spinal cord, yet the role of spinal reflex mechanisms underlying the benefits of RIC remains under explored. Therefore, this study aims to investigate effects of RIC on spinal reflex modulation in healthy adults, both independently and combined with balance training.

Key facts

Study ID

NCT06860464

Run by

East Carolina University

People needed

30

Starts

2025-03-06

Expected to finish

2026-12-01

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adults 18-40 years of age

You may not qualify if…

• Individuals with cognitive deficits or communication problems
• Individuals with impaired vision
• Individuals with balance disorders such as vestibular disorders, etc.
• Individuals who are pregnant
• Individuals with known cardiorespiratory dysfunctions
• Presence of lower extremity condition, injury, or surgery within last three months which could compromise training

Where it is running

• Swati Surkar — Greenville, North Carolina, United States

Full record on ClinicalTrials.gov

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