NoPro - Norwegian Hernia Prophylaxis Study

Recruiting now · Not applicable

Conditions studied: Incisional Hernia After Midline Laparotomy, Quality of Life (QOL), Burst Abdomen, Surgical Site Infections

In brief

A multicenter randomized controlled trial comparing midline laparotomy closures using the small-bite suture technique alone to those using the small-bite suture technique with an additional onlay prophylactic polypropylene mesh. The primary endpoint is the incidence of incisional hernias in both groups after one year.

Key facts

Study ID

NCT06858020

Run by

Sykehuset Innlandet HF

People needed

150

Starts

2025-02-17

Expected to finish

2028-12-01

Last updated by the study team

2025-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Surgery predominantly done my midline laparotomy
• Age 18 years old or older
• Written consent by patient/family
• Midline laparotomy with delayed closure
• No exclusion criteria

You may not qualify if…

• Age under 18 years
• Pregnancy
• Previous abdominal midline hernia mesh repair
• Abdominal compartment syndrome
• Linea alba closure not possible
• Life expectancy under six months
• Hernia in the midline with transverse diameter lager than 2 cm

Where it is running

• Innlandet Hospital Trust — Hamar, Norway (enrolling)

Full record on ClinicalTrials.gov

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