Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease

Recruiting now

Conditions studied: Parkinson's Disease

In brief

Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment and strabismus, frequently affects the quality of life in patients with Parkinson's disease. The investigators study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence and strabismus by integrating the patient-specific deep brain stimulation models and high-resolution eye-tracking measures. The knowledge gained will allow the investigators to find the most beneficial stimulation location and parameters for improving binocular coordination, strabismus, and vergence while preserving the ability to treat motor symptoms in Parkinson's disease.

Key facts

Study ID

NCT06857851

Run by

VA Office of Research and Development

People needed

80

Starts

2026-02-01

Expected to finish

2029-10-01

Last updated by the study team

2026-07-07

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Parkinson's disease with bilateral STN DBS
• Availability of pre-operative MR images (with a T1-weighted, gradient-echo sequence) and ability to get post-operative MRI or CT scans
• Hoehn and Yahr stage 2-4 when off medication, and a stable antiparkinsonian medication regimen and DBS parameter settings

You may not qualify if…

• Previous surgical therapy for Parkinson's disease (other than DBS)
• Dementia
• Clinically significant untreated depression or anxiety
• Clinical features suggestive of atypical parkinsonism

Where it is running

• Louis Stokes VA Medical Center, Cleveland, OH — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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