A Megastudy of Single-Session Interventions for Depression

Completed · Not applicable

Conditions studied: Depression - Major Depressive Disorder

In brief

This project aims to learn if new kinds of digital single-session interventions (SSIs) for depression could be effective for American adults. Many existing SSIs are delivered in a simple text-based format. However, it might be that different kinds of SSIs (in terms of both content and style) also have potential for scalable impact. Specifically, this study will investigate the effectiveness of 11 innovative SSIs by comparing them to a passive control and to an existing SSI with established efficacy.

Key facts

Study ID

NCT06856668

Run by

Northwestern University

People needed

7505

Starts

2025-03-11

Expected to finish

2025-06-24

Last updated by the study team

2025-06-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years old
• Able to read and write fluently in English
• Have enough access to the internet to complete two sessions over four weeks
• Score at least 10 on the PHQ-9 screen (suggesting moderate depression; Kroenke et al., 2001)
• Pass the bot check during the screening survey
• All participants who are randomized to an experimental condition (and therefore completed all baseline measures) will be included in analyses, except for participants who indicate at the end of either the baseline or week 4 session that they did not participate in the study seriously. Researchers will only keep data from the first survey session a participant begins.

Where it is running

• Northwestern University Medical Social Sciences — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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