Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose

Running, not enrolling · Not applicable

Conditions studied: Overdose

In brief

A hybrid type 1 study will be conducted to evaluate efficacy and preliminary implementation considerations for a novel intervention to promote uptake of drug checking services (DCS) and safer drug use behaviors among people who use drugs (PWUD) to reduce incidence of overdose (OD) and HIV and Hepatitis C virus (HCV) infections in San Diego County. Approximately 50 syringe services programs (SSPs) in the US now offer advanced drug checking services using test strips (TS) and Fourier Transform Infrared Spectrometry (FTIR), allowing people to submit drug samples with non-nominal identifiers and obtain personalized results. While most existing FTIRs offer some counseling, no theory-based interventions to increase FTIR uptake and promote post-FTIR adoption of safer drug use behaviors have been rigorously evaluated.

Key facts

Study ID

NCT06855836

Run by

University of California, San Diego

People needed

588

Starts

2025-03-03

Expected to finish

2029-05-01

Last updated by the study team

2026-04-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• A total of 588 PWUD participants will be recruited for the proposed study (MI-CHANCE). To be eligible to participate in this study, an individual must meet all of the following criteria:
• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Be aged ≥18 years at time of recruitment
• Must have used illicit opiates (e.g., heroin, fentanyl) and/or methamphetamine ≤1 week prior to recruitment date
• Live in San Diego County with no plans to permanently move over the next 30 months
• Have not previously used the FTIR drug checking service
• Enrolled into ongoing prospective cohort study La Frontera (the border) (existing or new participants)
• Enrollment will be capped so that <50% of the sample reports only using methamphetamine to ensure that the sample is comprised primarily of people who use opiates who are at greatest risk of OD. Recruitment will be done through targeted sampling at hotspots as well as homeless encampments, shelters and outreach through social media.

You may not qualify if…

• An individual who meets any of the following criteria will be excluded from participation in this study:
• Not being able to provide a signed and dated informed consent form
• Not willing to comply with all study procedures and availability for the duration of the study
• Currently enrolled in another randomized controlled trial
• Not having used illicit opiates (e.g., heroin, fentanyl), methamphetamine ≤1 week prior to recruitment date
• Having used CheckSD (i.e. drug testing with TS+FTIR)
• Participated in the MI-CHANCE pilot

Where it is running

• MI CHANCE - Park Blvd — San Diego, California, United States

Full record on ClinicalTrials.gov

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