Families Left Behind

Recruiting now · Not applicable

Conditions studied: Grief, Grief Disorder, Prolonged, Overdose Accidental, Substance Use Disorders

In brief

The United States is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief. Those bereaved by overdose experience a unique form of grief characterized by feelings of guilt, shame, and blame, which can worsen their suffering and deter them from seeking help. Individuals coping with overdose loss often endure more severe health consequences compared to those grieving non-drug related deaths, including prolonged grief disorder, substance use disorders, PTSD, depression, and suicidal thoughts. Moreover, bereaved individuals, particularly those with a history of substance use, may engage in risky behaviors as a means of coping, further exacerbating the risk of overdose and mortality within this vulnerable population. Peer grief support interventions have emerged as a promising approach to assist those experiencing such losses. To combat these outcomes, we are collaborating with Peer Community Support Partners (PSCP) in a novel practice-research partnership to implement the RIVER peer grief support model. Though RIVER has shown success in community settings, it has yet to be rigorously evaluated. In a three-aim approach, this study aims to assess the effectiveness of the RIVER model while also enhancing and engaging grievers with support resources via medical examiner offices (MEOs), which routinely contact families during death investigations. This research represents a pivotal advancement in addressing the needs of the overlooked bereaved community, aligning with the NIH's Helping to End Addiction Long-term (HEAL) initiative to develop effective strategies against the opioid crisis. Together, community engagement and rigorous research efforts aim to enhance support for those affected by the tragedy of drug overdose.

Key facts

Study ID: NCT06854757
Run by: RAND
People needed: 340
Starts: 2025-06-13
Expected to finish: 2030-10-01
Last updated by the study team: 2025-08-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

people who lost a loved one to an unintentional drug overdose death within the past year
age 18 and older
fluently understand English or Spanish
have the capacity to give consent (e.g., excluding those with severe cognitive impairment, those in active psychosis, and those with developmental disabilities).

You may not qualify if…

people who need hospitalization for psychiatric symptoms or substance use disorders. (Note, people who use drugs but who do not require hospitalization will be included.)
people have active suicidal ideation
people who lost someone to a drug overdose death more than one year ago
people who lost someone to a drug overdose death that was suicidal in nature or of undetermined intent

Where it is running

Jefferson County Coroner/Medical Examiner's Office — Birmingham, Alabama, United States (enrolling)
San Diego County Medical Examiner Office — San Diego, California, United States (enrolling)
Connecticut Office of the Chief Medical Examiner — Farmington, Connecticut, United States (enrolling)
Peer Support Community Partners — Watertown, Massachusetts, United States

Full record on ClinicalTrials.gov

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