Prokinetics and Body Surface Gastric Mapping in Dyspeptic Patients: Baseline and Treatment Effects
Recruiting now
Conditions studied: Gastroparesis, Functional Dyspepsia
In brief
Functional dyspepsia and gastroparesis are common stomach disorders with symptoms like early satiety, nausea, and abdominal pain, and are often evaluated with gastric emptying tests, although the correlation with symptoms is weak. Prokinetic agents (e.g., metoclopramide, erythromycin) and symptom modulators (e.g., nortriptyline, mirtazapine) are commonly used, but selecting the right medication can be difficult, as it's often based on symptoms rather than the underlying gastric issues. Body Surface Gastric Mapping (BSGM) using the Gastric Alimetry device is a novel, non-invasive tool to assess gastric myoelectrical activity and symptoms. This study aims to perform two BSGM recordings-one before and one after medical therapy-to understand how medications affect gastric function and identify baseline BSGM factors that could predict responses to treatment, potentially guiding tailored therapies based on individual gastric dysfunction.
Key facts
- Study ID
- NCT06854120
- Run by
- University of Auckland, New Zealand
- People needed
- 125
- Starts
- 2025-02-26
- Expected to finish
- 2028-08-26
- Last updated by the study team
- 2026-06-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients 18 years of age and older
- Diagnosis of gastroparesis and/or functional dyspepsia
- Being prescribed a prokinetic agent or symptom modulator for their clinical care
- Able to undergo BSGM recording both before and during treatment
- Able to give informed consent for undergoing a baseline BSGM recording and an additional recording while on treatment
You may not qualify if…
- Under 18 years of age
- Prior surgery on esophagus, stomach (appendectomy and cholecystectomy are allowed)
- History of skin allergies or a history of extreme sensitivity to cosmetics or lotions
- Pregnant women
- No vulnerable groups such as prisoners, individuals with known cognitive impairment, or institutionalized individuals be involved
Where it is running
- Western Sydney University — Sydney, New South Wales, Australia (enrolling)
- Te Whatu Ora Waitemata — Auckland, Auckland, New Zealand (enrolling)
- Temple University — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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