Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation
Recruiting now · Not applicable
Conditions studied: Chronic Hepatitis B Virus
In brief
Natural Killer (NK) and B cell immune responses occur during the early stages of infection and are essential to eradicate it. Yet, chronic hepatitis B (CHB) infection occurs because the antiviral immune response is insufficient. In both NK and B cell studies we will explore the genetic alterations that occur during the varied chronic stages of the disease. We believe that our findings will allow us to understand the molecular signature of NK and B cells in the context of HBV infection.
Key facts
- Study ID
- NCT06853886
- Run by
- University Hospital, Limoges
- People needed
- 140
- Starts
- 2025-08-12
- Expected to finish
- 2028-10-01
- Last updated by the study team
- 2026-05-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male or female, age ≥18 years old
- HBV infection or chronic HBV infection untreated or treated with a nucleoside or nucleotide analog
- Willing and able to provide written informed consent
- Affiliated with a social securityregimen
- Healthy volunteer must meet all of the following inclusion criteria to be eligible for participation in this study:
- Male or female, age between 18 and 80 years
- Willing and able to provide written informed consent
You may not qualify if…
- Co-infection with HCV, HIV or HDV (or HBV for healthy volunteer)
- Acute hepatitis in the year preceding recruitment
- Other liver diseases : alcohol, obesity (BMI>30), diabetes, metabolic syndrome (dyslipidemia and/or known hypertension) - Underlying immunological or cancerous diseases
- Patient with a disability that prevents him/her from fully understanding the requirements of the trial - Patient under court protection, guardianship or curatorship
- Pregnant or breast-feeding women.
- Secondary exclusion criteria:
- A healthy volunteer whose vaccination status does not match that expected on the basis of serological results
- Positive blood pregnancy test on inclusion
- Positive HCV, HIV or HDV test in a patient
- Positive HBV, HCV, HIV or HDV test in a healthy volunteer
Where it is running
- Centre d'Investigation Clinique — Limoges, France (enrolling)
- Limoges University Hospital — Limoges, France (enrolling)
- Hospice civils de Lyon — Lyon, France (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.