Treatment of Sleep Apnea to Improve Metabolic Health
Recruiting now
Conditions studied: Sleep Apnea, Obstructive, Metabolism, CPAP, Patients Above 18 Years
In brief
Diabetes and prediabetes prevail among obstructive sleep apnea (OSA) patients. OSA and short sleep both detrimentally affect glycemic control regardless of obesity. With 1 in 10 adults having diabetes, 1 in 10 with prediabetes, and an estimated 600,000 affected by OSA in Sweden, attaining glycemic control is crucial. Though continuous positive airway pressure (CPAP) is the most effective treatment for OSA, its application lacks personalization, ignoring factors like comorbidities and sleep duration. Key unanswered questions regarding CPAP's impact on glycemic control include: 1) Does high CPAP adherence optimize glycemic control? 2) Should short sleep be addressed alongside OSA treatment for glycemic control? 3) Does long-term diabetes hinder CPAP's glycemic control efficacy? The purpose of this project is to enable precision health in CPAP treatment and producing a personalized treatment model for achieving glycemic control in patients with OSA, treated with CPAP. Taking advantage of a large unique patient cohort (600 patients followed over 18 months) with extensive and objective measures on CPAP adherence, OSA reduction, sleep duration, as well as information on comorbidities, anthropometric, lifestyle data, and a wide range of biomarkers related to glycemic control. This comprehensive approach and in-depth analysis will address these questions and generate a personalized treatment strategy for glycemic control in CPAP-treated OSA patients.
Key facts
- Study ID
- NCT06848647
- Run by
- Uppsala University
- People needed
- 600
- Starts
- 2024-05-13
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2025-02-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients diagnosed with obstructive sleep apnea
- Planned for CPAP treatment
- 18 years and above
You may not qualify if…
- Patient not wanting to participate in study
- Non-Swedish speaking
- Judged by physician as non-fit for study participation
Where it is running
- Uppsala University — Uppsala, Uppsala County, Sweden (enrolling)
Full record on ClinicalTrials.gov
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