Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

Recruiting now

Conditions studied: Endometriosis, Endometrioma

In brief

The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy

Key facts

Study ID: NCT06847685
Run by: Johns Hopkins University
People needed: 140
Starts: 2025-02-01
Expected to finish: 2030-02-01
Last updated by the study team: 2026-03-09

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Subject must be a healthy woman between the ages of 18 and 45 years.
Women with diagnosed endometriosis or infertility (cases).
Women without a diagnosis of endometriosis or infertility (controls).
Subject must have regular menstrual cycles.
Subject must have a body mass index (BMI) between 18 and 40.
Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information.
No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV.
For IVF study subjects, a minimum endometrial thickness of 7mm at the time of sample collection.

You may not qualify if…

Pregnant women.
Study subjects with endometrial cancer.
Study subjects with a history of endometrial ablation.
Study subjects with undiagnosed uterine bleeding.
Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity).
Study subjects with an intrauterine device (IUD).

Where it is running

Johns Hopkins Hospital — Baltimore, Maryland, United States (enrolling)
University of Georgia — Athens, Georgia, United States
Rutgers University — Piscataway, New Jersey, United States

Full record on ClinicalTrials.gov

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