Tailored Electronic Intervention to Improve Therapy in a Diverse Cohort of Patients With Heart Failure

Completed · Not applicable

Conditions studied: Heart Failure

In brief

Recent medical guidelines for the management of heart failure (HF) have established a combination of specific classes of medications as the best treatment for patients with heart failure with reduced ejection fraction (HFrEF). However, studies have shown that these medications, known together as guideline-directed medical therapy (GDMT), are not being used in clinical practice less often than they could be. Several tools to promote broader use of these treatments (including patient checklists) have shown promise for increasing use of GDMT. However, these tools have not been broadly implemented within large health systems. The goal of this study is to see if using these tools broadly within cardiology clinics will increase the use of GDMT. This study is important because it could help improve the use of GDMT, which may lead to improved patient care and outcomes.

Key facts

Study ID

NCT06847438

Run by

Emory University

People needed

3966

Starts

2025-03-24

Expected to finish

2026-06-15

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ejection fraction (EF) less than or equal to 40% by echocardiogram performed in the prior 18 months
• Diagnosis of heart failure

You may not qualify if…

• Heart failure (HF) etiology for which GDMT is not indicated: including hypertrophic or restrictive cardiomyopathy (e.g. amyloid cardiomyopathy), constrictive pericarditis, or complex congenital heart disease
• End-stage HF requiring continuous inotrope infusion, heart transplant, or left ventricular assist device
• Estimated glomerular filtration rate (eGFR) < 15 mL/min/1.73m\^2
• Any conditions other than HF that are likely to alter the patient's status over 6 months, indicated by active hospice status

Where it is running

• Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
• Emory University Hospital Midtown — Atlanta, Georgia, United States
• Emory University Hospital — Atlanta, Georgia, United States
• Emory Johns Creek Hospital — Johns Creek, Georgia, United States

Full record on ClinicalTrials.gov

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