Real-world Effectiveness and Safety of Trastuzumab Deruxtecan in Patients With Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma in China

Recruiting now

Conditions studied: HER2-positive Gastric Cancer, HER2-positive Gastroesophageal Junction

In brief

Trastuzumab deruxtecan's (T-DXd's) efficacy and safety has been confirmed in traditional clinical trials, there is a lack of real-world evidence, especially among Chinese patients. The objective of this study is to evaluate real-world effectiveness and safety profile of T-DXd by collecting real-world data treating in patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal junction adenocarcinoma.

Key facts

Study ID

NCT06846996

Run by

Daiichi Sankyo

People needed

260

Starts

2025-02-27

Expected to finish

2027-07-31

Last updated by the study team

2025-07-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• The Affiliated Hospital of Xuzhou Medical University — Xuzhou, China (enrolling)
• Henan Cancer Hospital — Zhengzhou, China (enrolling)
• Jiangmen Central Hospital — Jiangmen, China (enrolling)
• Nanjing Drum Tower Hospital — Nanjing, China (enrolling)
• Shanghai GoBroad Cancer Hospital — Shanghai, China (enrolling)
• Ruijin Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, China (enrolling)
• Zhongshan Hospital — Shanghai, China (enrolling)
• Huadong Hospital Affiliated to Fudan University — Shanghai, China (enrolling)
• Cancer Hospital of Shantou University Medical College — Shantou, China (enrolling)
• Shanxi Cancer Hospital — Taiyuan, China (enrolling)
• Taizhou Hospital of Zhejiang Province — Taizhou, China (enrolling)
• The Affiliated Hospital of Xi'an Jiaotong University — Xi'an, China (enrolling)
• China-Japan Friendship Hospital — Beijing, China (enrolling)
• Peking University First Hospital — Beijing, China (enrolling)
• Beijing Cancer Hospital — Beijing, China (enrolling)
• Beijing GoBroad Hospital — Beijing, China (enrolling)
• Changzhi People's Hospital — Changzhi, China (enrolling)
• Fujian Cancer Hospital — Fuzhou, China (enrolling)
• Guangdong Provincial People's Hospital — Guangzhou, China (enrolling)
• The First Affiliated Hospital, Sun Yat-sen University — Guangzhou, China (enrolling)
• Affiliated Cancer Hospital and Institute of Guangzhou Medical University — Guangzhou, China (enrolling)
• Guangdong Hospital of Traditional Chinese Medicine — Guangzhou, China (enrolling)
• Hainan General Hospital — Haikou, China (enrolling)
• Zhejiang Cancer Hospital — Hangzhou, China (enrolling)
• The Second Affiliated Hospital Zhejiang University School of Medicine — Hangzhou, China (enrolling)

Full record on ClinicalTrials.gov

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