Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients (AR882-301)

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Gout, Arthritis, Gouty, Hyperuricemia, Gout Chronic

In brief

This study will assess the serum uric acid lowering effect and safety of AR882 in gout patients at two doses compared to placebo over 12 months

Key facts

Study ID

NCT06846515

Run by

Arthrosi Therapeutics

People needed

750

Starts

2025-03-11

Expected to finish

2026-10-01

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of gout
• Occurrence of ≥ 2 self-reported gout flares in the last 12 months
• Body weight no less than 50 kg
• Patients who are NOT on approved urate-lowering therapy (ULT) must have sUA ≥ 7 mg/dL
• Patients who are on medically appropriate ULT must have sUA > 6 mg/dL
• Serum creatinine must be < 3.0 mg/dL and estimated CLcr ≥ 30 mL/min

You may not qualify if…

• Malignancy within 5 years, except for successfully treated basal or squamous cell carcinoma of the skin
• Pregnant or breastfeeding
• History of symptomatic kidney stones within the past 6 months

Where it is running

• Arthrosi Investigative Site (616) — Huntsville, Alabama, United States
• Arthrosi Investigative Site (680) — Peoria, Arizona, United States
• Arthrosi Investigative Site (640) — Phoenix, Arizona, United States
• Arthrosi Investigative Site (617) — Little Rock, Arkansas, United States
• Arthrosi Investigative Site (614) — Garden Grove, California, United States
• Arthrosi Investigative Site (618) — La Mesa, California, United States
• Arthrosi Investigative Site (687) — La Mesa, California, United States
• Arthrosi Investigative Site (655) — La Palma, California, United States
• Arthrosi Investigative Site (632) — Lincoln, California, United States
• Arthrosi Investigative Site (605) — Lomita, California, United States
• Arthrosi Investigative Site (675) — Long Beach, California, United States
• Arthrosi Investigative Site (603) — Santa Monica, California, United States
• Arthrosi Investigative Site (672) — Tarzana, California, United States
• Arthrosi Investigative Site (656) — Thousand Oaks, California, United States
• Arthrosi Investigative Site (660) — Aurora, Colorado, United States
• Arthrosi Investigative Site (669) — Colorado Springs, Colorado, United States
• Arthrosi Investigative Site (612) — Fort Collins, Colorado, United States
• Arthrosi Investigative Site (665) — Cooper City, Florida, United States
• Arthrosi Investigative Site (613) — Jupiter, Florida, United States
• Arthrosi Investigative Site (611) — Miami, Florida, United States
• Arthrosi Investigative Site (644) — Miami, Florida, United States
• Arthrosi Investigative Site (694) — Palmetto Bay, Florida, United States
• Arthrosi Investigative Site (615) — Sanford, Florida, United States
• Arthrosi Investigative Site (600) — Tampa, Florida, United States
• Arthrosi Investigative Site (620) — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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