Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Recruiting now · Phase 3
Conditions studied: Relapsing Multiple Sclerosis
In brief
The purpose of this Phase 3b study is to assess the efficacy, safety and tolerability of remibrutinib after switching from ocrelizumab and compared to continuous ocrelizumab treatment, in patients living with relapsing multiple sclerosis (plwRMS).
Key facts
- Study ID
- NCT06846281
- Run by
- Novartis Pharmaceuticals
- People needed
- 360
- Starts
- 2025-06-23
- Expected to finish
- 2031-06-24
- Last updated by the study team
- 2026-06-26
Who can join
Age: 40 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California Irvine — Irvine, California, United States (enrolling)
- Medstar Washington Hospital Center — Washington D.C., District of Columbia, United States (enrolling)
- Neurology of Central FL Res Ctr — Altamonte Springs, Florida, United States (enrolling)
- University of Florida — Gainesville, Florida, United States (enrolling)
- Neurology Associates PA — Maitland, Florida, United States (enrolling)
- Aqualane Clinical Research — Naples, Florida, United States (enrolling)
- Advent Health Orlando — Orlando, Florida, United States (enrolling)
- Orlando Health Clinical Trials — Orlando, Florida, United States (enrolling)
- Tallahassee Neurological Clinic — Tallahassee, Florida, United States (enrolling)
- University Of South Florida — Tampa, Florida, United States (enrolling)
- Vero Beach Neurology — Vero Beach, Florida, United States (enrolling)
- Rush University Medical Center — Chicago, Illinois, United States (enrolling)
- University of Kansas Hospital — Kansas City, Kansas, United States (enrolling)
- MedStar Montgomery Medical Center — Olney, Maryland, United States (enrolling)
- Tufts Medical Center — Boston, Massachusetts, United States (enrolling)
- Lahey Hospital and Medical Center — Burlington, Massachusetts, United States (enrolling)
- Neurology Center of New England PC — Foxborough, Massachusetts, United States (enrolling)
- Michigan Institute of Neurological — Farmington Hills, Michigan, United States (enrolling)
- Memorial HC Ins for Neuroscience — Owosso, Michigan, United States (enrolling)
- WA Uni School Of Med — St Louis, Missouri, United States (enrolling)
- Cleveland Clinic Foundation — Las Vegas, Nevada, United States (enrolling)
- Holy Name Medical Center — Teaneck, New Jersey, United States (enrolling)
- University of New Mexico — Albuquerque, New Mexico, United States (enrolling)
- SUNY Buffalo The Jacobs Neuro Inst — Buffalo, New York, United States (enrolling)
- Perseverance Research Center — Scottsdale, Arizona, United States (enrolling)
Full record on ClinicalTrials.gov
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