Diagnosing peRipheral Lung Lesions With CRYO Biopsies

Recruiting now · Not applicable

Conditions studied: Lung Cancer, Peripheral Lung Lesions

In brief

Lung cancer is the leading course of cancer related deaths world-wide. Lung cancer screening will increase the number of small lung lesion in need of biopsy to confirm the diagnosis. Obtaining lung biopsies with a bronchoscopy has the lowest risk of complications (1-2%) compared to other modalities such as transthoracic needle biopsy (20%), however diagnostic yield needs improvement. Currently a diagnosis is established in 50- 70% of the bronchoscopic procedures depending on the step-up. One way to improve the yield would be by using a cryo probe through the bronchoscope which freezes a small part of the lung for extraction, and thereby provides larger biopsies for examination. This will increase the chances of obtaining sufficient material from a small lesion to determine the diagnosis. The DR CRYO study will compare cryo biopsies to forceps biopsies for the diagnosis of peripheral lung lesions. We hope that the cryo biopsies can improve the diagnostic capabilities of bronchoscopy and provide better biopsies for tumor marker analyses. The project is relevant both for patients undergoing diagnostic work-up for lung cancer in early stages .

Key facts

Study ID

NCT06844344

Run by

Odense University Hospital

People needed

100

Starts

2025-03-01

Expected to finish

2027-02-01

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Patients undergoing diagnostic work-up for lung cancer due to a lung lesion surrounded by normal lung tissue (identified by CT)
• Age 18 or above
• Bronchoscopy with planned forceps sampling from the lesion

You may not qualify if…

• - Pregnancy
• Not able to provide informed consent.

Where it is running

• Odense University Hospital — Odense, Region Syddanmark, Denmark (enrolling)
• Næstved Hospital — Næstved, Region Sjælland, Denmark

Full record on ClinicalTrials.gov

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