Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss

Starting soon · Not applicable

Conditions studied: Amputation of Lower Limb

In brief

The goal of clinical trial is to assess an integrated, patient-centered strategy combining user preference-based prosthetic foot prescription and subsequent targeted physical therapy to maximize satisfaction and mobility outcomes for Veterans and others with lower limb loss. The main aims it will address are: * Assess the effect of prosthetic foot selection based on experiential preference as determined using a variable stiffness foot on mobility and satisfaction * Assess the effect of a targeted physical therapy intervention following preference-based foot selection on mobility, balance, and satisfaction? Participants will walk with an emulator prosthetic foot to experience three different conditions that emulate different commercial feet to determine their most- and least-preferred foot. Participants' satisfaction, perceived mobility, and functional mobility will be measured and compared between their most- and least-preferred feet using the corresponding commercial feet. Participants will then be randomly assigned to receive either the standard-of-care (control group) or personalized physical therapy intervention for eight weeks using that preferred prosthetic foot. Participants' satisfaction, mobility, and balance will be measured pre- and post-intervention.

Key facts

Study ID

NCT06844305

Run by

Northwestern University

People needed

50

Starts

2026-12-01

Expected to finish

2029-05-01

Last updated by the study team

2026-06-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unilateral transtibial amputation;
• At least 6 months post-amputation;
• A comfortable-fitting prosthetic socket that can be used with endoskeletal components;
• Sufficient walking abilities to safely complete study activities.

You may not qualify if…

• Major contralateral limb amputation LLL on the contralateral limb;
• Currently receiving physical therapy related to gait training or prosthesis use.

Where it is running

• Northwestern University Prosthetics-Orthotics Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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