Predictors of Poor Prognosis in HFpEF

Recruiting now

Conditions studied: HFpEF

In brief

Patients with HFpEF who have undergone meticulous clinical and instrumental evaluation (including diastolic exercise testing) between 2013 and 2020, will be followed up for at least 3 years.

Key facts

Study ID

NCT06844032

Run by

National Medical Research Center for Cardiology, Ministry of Health of Russian Federation

People needed

500

Starts

2022-01-31

Expected to finish

2026-12-31

Last updated by the study team

2026-04-17

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed and data informed consent;
• New York Heart Association (NYHA) class II-III heart failure;
• Left ventricular ejection fraction > 50%;
• Elevated LV filling pressures assessed by echocardiography at rest or at peak exercise.

You may not qualify if…

• Evidence of myocardial ischemia during stress echocardiography;
• Significant lesions of the main coronary arteries;
• Genetic forms of HFpEF (HCM, amyloidosis, Fabry disease, glycogen storage diseases etc.);
• Peripartum cardiomyopathy, chemotherapy-induced cardiomyopathy, viral myocarditis, isolated right-sided HF without left-sided structural disease, constrictive pericarditis, significant pericardial effusion;
• Significant lung disease (severe lung disease requiring home oxygen or chronic oral steroid therapy);
• Primary pulmonary artery hypertension;
• Significant left-sided structural valve disease;
• Anemia (Hb < 100 g/L);
• Impaired renal function, defined as estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (CKD-EPI);
• Non-cardiac conditions that complicate/exclude participation in the study;
• Exacerbation of heart failure less than 3 months prior to study entry.

Where it is running

• Federal State Budgetary Institution NATIONAL MEDICAL RESEARCH CENTRE OF CARDIOLOGY NAMED AFTER ACADEMICIAN E.I.CHAZOV. of the Ministry of Health of the Russian Federation — Moscow, Russia (enrolling)

Full record on ClinicalTrials.gov

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