Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

Recruiting now · Phase 2

Conditions studied: Aphasia, Stroke, Aphasia Following Cerebral Infarction, Aphasia, Acquired

In brief

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment

Key facts

Study ID

NCT06842745

Run by

University of Pennsylvania

People needed

24

Starts

2025-02-11

Expected to finish

2026-08-31

Last updated by the study team

2026-03-05

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Left Hemisphere stroke
• Stroke occurred more than 6 months ago
• Mild Aphasia (WAB AQ score > 85)
• Proficient in English

You may not qualify if…

• Ongoing substance or alcohol abuse
• Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)
• Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)
• Pacemaker or cardiac defibrillator
• Diagnosis of tinnitus
• Epilepsy, or seizure in the past 6 months

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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