Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

Recruiting now · Not applicable

Conditions studied: Amputation

In brief

This clinical trial evaluates two surgical techniques (targeted muscle re-innervation \[TMR\] and regenerative peripheral nerve interfaces \[RPNI\]) alone and in combination for the alleviation of chronic residual limb and phantom limb pain in cancer patients who have had an amputation. Chronic residual limb pain and phantom limb pain are debilitating outcomes of traumatic and oncologic amputation. Emerging microsurgical treatments for post-amputation pain are very promising. TMR and RPNI are both approved surgical techniques that involve connecting cut nerves to parts of the muscle as a way to heal and protect the nerves. This trial evaluates these techniques alone and in combination for the treatment of residual and phantom limb pain in cancer patients who have received an amputation.

Key facts

Study ID

NCT06840262

Run by

M.D. Anderson Cancer Center

People needed

45

Starts

2020-08-10

Expected to finish

2027-02-02

Last updated by the study team

2025-09-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients greater than or equal to 18 years of age who are receiving an amputation for oncologic reasons
• Patients with available mixed major nerves and donor motor nerves in the amputation stump or reconstructive tissue
• Patients able to complete informed consent

You may not qualify if…

• Patients under 18 years of age
• Patients unable to give consent
• Patients receiving an amputation for non-oncologic purposes
• Patients with amputations performed for immediate palliation (life expectancy less than 3 months), as this technique takes a minimum of 3-6 months for effect
• Patients with multiple limb amputations
• Patients receiving nerve management in a delayed fashion (patients who have previously received an amputation and present with neuroma)

Where it is running

• M D Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.