Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity

Recruiting now

Conditions studied: OVARIAN STIMULATION

In brief

Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles. Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.

Key facts

Study ID

NCT06839274

Run by

ART Fertility Clinics LLC

People needed

100

Starts

2025-03-27

Expected to finish

2026-12-31

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older, up to 48. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Reproductive age group: 18 -48
• undergoing ovarian stimulation for oocyte vetrification
• undergoing IVF/ ICSI with PGT-A / PGT-M / PGT- Sr
• less than or equal to 3 AFC on initiation of stimulation
• follicular phase stimulation

You may not qualify if…

• surgically retrieved sperm

Where it is running

• ART Fertility Clinics — Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates (enrolling)

Full record on ClinicalTrials.gov

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