Rehabilitation Exercise and Education of Airway Clearance Technique in NTM-PD: A Prospective Cohort Study

Recruiting now

Conditions studied: Nontuberculous Mycobacterial Pulmonary Disease

In brief

* The goal of this observational study is to evaluate the effects of pulmonary rehabilitation and airway clearance education in adults with nontuberculous mycobacterial pulmonary disease (NTM-PD). The main questions it aims to answer are: * Does pulmonary rehabilitation and airway clearance training improve lung function, symptom relief, and quality of life in patients with NTM-PD? * Does this non-pharmacological intervention contribute to better sputum culture conversion rates? * Participants will: * Undergo pulmonary rehabilitation and airway clearance training over an 8-week period (biweekly sessions). * Receive evaluations at baseline, during the intervention, and follow-up assessments at 2 months, 6 months, and final study visit. * Undergo tests including pulmonary function tests (PFT), symptom assessments, bacteriologic evaluations, radiographic imaging (CT/X-ray), and quality of life surveys (EQ-5D-5L, CAT score). * This study aims to provide clinical evidence supporting the role of non-pharmacological treatments in the management of NTM-PD, potentially informing future treatment guidelines and improving patient outcomes.

Key facts

Study ID

NCT06838442

Run by

Seoul National University Bundang Hospital

People needed

500

Starts

2025-04-21

Expected to finish

2028-11-25

Last updated by the study team

2025-06-29

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 20 years or older at the time of enrollment.
• Diagnosis of nontuberculous mycobacterial pulmonary disease (NTM-PD) according to the 2020 American Thoracic Society (ATS) guidelines.
• Identification of clinically significant NTM species, including:
• Mycobacterium avium / Mycobacterium intracellulare / Mycobacterium abscessus / Mycobacterium massiliense / Mycobacterium kansasii /
• Able to undergo pulmonary rehabilitation and airway clearance training as part of the study protocol.
• Willing to provide written informed consent to participate in the study.

You may not qualify if…

• Currently pregnant or actively breastfeeding.
• Unable to participate in pulmonary rehabilitation due to severe mobility impairment or neuromuscular disorders.
• History of massive hemoptysis or other medical conditions where airway clearance techniques may be contraindicated.

Where it is running

• Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea (enrolling)

Full record on ClinicalTrials.gov

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