Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury
Recruiting now · Phase 1/Phase 2
Conditions studied: TBI Traumatic Brain Injury
In brief
Propranolol primarily acts as a non-selective beta blocker, blocking both beta-1 and beta-2 adrenergic receptors, while carvedilol exhibits a broader spectrum of action by also blocking alpha-1 adrenergic receptors. The receptor blockade profile of a beta blocker can influence its physiological effects and potential therapeutic benefits in TBI. Therefore, the variation in receptor selectivity may result in differences in their impact on secondary brain injury processes and patient outcomes.
Key facts
- Study ID
- NCT06836856
- Run by
- Mansoura University
- People needed
- 100
- Starts
- 2025-01-20
- Expected to finish
- 2025-06-01
- Last updated by the study team
- 2025-04-02
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with moderate \& severe TBI detected on admission by CT scan and GCS score of ≤ 13 who either do not have any other injuries or only have associated minor injuries.
- Minor injuries are defined as presence of any of the following:
- Mild intraperitoneal free fluid (IPFF) observed through abdominal ultrasound.
- mild lung contusion detected in the chest CT scan.
- hemothorax or pneumothorax present without accompanying symptoms of hypoxia, tachypnea, or respiratory distress.
- simple limb fractures.
You may not qualify if…
- Patients on pre-injury beta-blocker therapy.
- Patients with any bronchospastic conditions.
- Patients with active acute coronary syndrome.
- TBI with GCS ≤ 13 with associated major injuries defined as the presence of any of the following:
- Moderate \& marked IPFF requiring surgical intervention ( laparotomy ).
- moderate \& marked lung contusion, pneumothorax \& hemothorax with accompanying symptoms of hypoxia, tachypnea, lower limbs, or limb amputation.
- Compound fracture in the upper or lower limb.
- Open Faciomaxillary trauma.
- Patients with persistent shock (systemic blood pressure <100 mmHg, base deficit > 4, or oliguria , HR < 60 b/min ) after > one week of admission.
Where it is running
- Zagazig University Hospitals, Zagazig, — Zagazig, Egypt (enrolling)
- Zagazig University Hospitals — Zagazig, Egypt
Full record on ClinicalTrials.gov
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