PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

Recruiting now · Not applicable

Conditions studied: Ventilation Therapy, PEEP, Occult, CPR, Cardiac Arrest (CA)

In brief

Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.

Key facts

Study ID

NCT06836830

Run by

Muehlenkreiskliniken, MKK

People needed

600

Starts

2025-06-01

Expected to finish

2026-10-31

Last updated by the study team

2025-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults >= 18 years
• non-traumatic OHCA
• mechanical ventilation via airway device

You may not qualify if…

• Patients < 18 years,
• traumatic cause of OHCA,
• no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)

Where it is running

• Emergency Medical Services — Gütersloh, North Rhine-Westphalia, Germany (enrolling)
• JWK Minden — Minden, North Rhine-Westphalia, Germany (enrolling)
• Emergency Medical Services — Osnabrück, Germany (enrolling)

Full record on ClinicalTrials.gov

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