Impact of Anesthesia, Positive Pressure Ventilation and Modality of Imaging on the Echocardiographic Assessment of the Severity of Aortic Regurgitation

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Conditions studied: Aortic Regurgitation Disease, Aortic Insufficiency

In brief

The goal of this observational study is to assess the impact of imaging modality (trans-thoracic echo (TTE) vs trans-esophageal echo (TEE)), anesthesia and positive pressure ventilation on the grading of aortic insufficiency. Patients scheduled for cardiac surgery and in whom a TEE is going to be performed intra-operatively will be enrolled. The grading of the aortic insufficiency will be compared between a TTE performed immediately before the induction of general anesthesia end the TEE performed after induction of general anesthesia.

Key facts

Study ID

NCT06835946

Run by

University of Liege

People needed

100

Starts

2025-03-01

Expected to finish

2027-04-01

Last updated by the study team

2025-04-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Known aortic regurgitation of any grade
• Scheduled for a cardiac surgery procedure during which a trans-esophageal echo is planned.

You may not qualify if…

• Non sinus rhythm
• Mitral regurgitation more than mild.
• Pre-operative critical state (according to the definition of the EuroSCORE II)
• Presence of a prosthetic aortic valve
• Contra-indication to trans-esophageal echo

Where it is running

• Centre Hospitalier Universitaire de Liège — Liège, Belgium (enrolling)

Full record on ClinicalTrials.gov

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