Dextran 40 Plus Ringer's Lactate Vs. Ringer's Lactate Alone for Fluid Resuscitation in Acute Pancreatitis
Recruiting now · Not applicable
Conditions studied: Acute Pancreatitis (AP), Acute Pancreatic Fluid Collection, Fluid Resuscitation
In brief
This clinical trial aims to learn if a combination of Dextran 40 and Ringer's lactate solution can improve fluid resuscitation in mild and moderate acute pancreatitis (AP) and prevent complications. The main questions it aims to answer are: Does early fluid resuscitation with Dextran 40 plus Ringer's lactate improve patient outcomes compared to Ringer's alone? Does this treatment reduce inflammation, organ failure, and the need for intensive care unit (ICU) admission? Researchers will compare Dextran 40 plus Ringer's lactate to Ringer's alone to see if the combination therapy is more effective in reducing disease severity and complications. Participants will: Receive either Dextran 40 plus Ringer's lactate (1:3 ratio) or Ringer's lactate alone. Have blood tests every 24 hours to measure inflammation and organ function. Be monitored for changes in disease severity, need for ICU admission, and hospitalization duration. This study will help determine the best fluid resuscitation strategy for treating mild and moderate acute pancreatitis.
Key facts
- Study ID
- NCT06835023
- Run by
- Satu Mare County Emergency Hospital
- People needed
- 100
- Starts
- 2022-01-10
- Expected to finish
- 2025-05-12
- Last updated by the study team
- 2025-02-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- adults (≥18 years) diagnosed with mild or moderate acute pancreatitis
- must provide written informed consent for study participation.
You may not qualify if…
- patients who decline to provide informed consent.
- patients are non-compliant with treatment and follow-up visits.
- pregnant individuals.
- patients requiring concomitant treatment that is contraindicated within the study protocol.
- patients who develop conditions that contraindicate the administration of the investigational medication.
- patients experiencing severe adverse reactions necessitating treatment discontinuation.
Where it is running
- Spitalul Judetean de Urgenta Satu Mare — Satu Mare, Satu Mare County, Romania (enrolling)
Full record on ClinicalTrials.gov
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