A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)
Completed · Phase 1 · Has a placebo group
Conditions studied: Glabellar Lines
In brief
The objective of this Phase 1 study is to assess the safety and efficacy of single treatment of AGN-151586 and of OnabotulinumtoxinA in the glabellar complex of participants with moderate to severe glabellar lines (GL).
Key facts
- Study ID
- NCT06834789
- Run by
- AbbVie
- People needed
- 132
- Starts
- 2025-02-18
- Expected to finish
- 2025-11-03
- Last updated by the study team
- 2025-11-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Has moderate or severe glabellar lines (GL) at maximum frown as assessed by both the investigator and participant using the Facial Wrinkle Scale (FWS).
- Must be in good health as per investigator's judgment based on medical history, physical examination, vital sign measurements, 12-lead ECG parameters, clinical laboratory evaluations, and neurological assessment.
You may not qualify if…
- Active infection or dermatological condition at the treatment injection sites.
- History of immunization to any botulinum neurotoxin serotype or hypersensitivity to any botulinum neurotoxin serotype or any other constituents of the study drug or its excipients, and/or other products in the same class.
Where it is running
- Investigate MD /ID# 270771 — Scottsdale, Arizona, United States
- Eye Research Foundation /ID# 270827 — Newport Beach, California, United States
- Marcus Facial Plastic Surgery /ID# 270770 — Redondo Beach, California, United States
- Skin Research Institute LLC /ID# 270831 — Coral Gables, Florida, United States
- Skincare Physicians /ID# 271018 — Chestnut Hill, Massachusetts, United States
- Wilmington Dermatology Center /ID# 270828 — Wilmington, North Carolina, United States
- Austin Institute for Clinical Research - Pflugerville /ID# 270834 — Pflugerville, Texas, United States
- SkinDC /ID# 270932 — Arlington, Virginia, United States
Full record on ClinicalTrials.gov
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