Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome

Recruiting now · Phase 4

Conditions studied: Turner Syndrome, Primary Ovarian Insufficiency (Poi)

In brief

This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed hormone replacement therapy (HRT).

Key facts

Study ID

NCT06834594

Run by

Children's Mercy Hospital Kansas City

People needed

40

Starts

2025-07-31

Expected to finish

2026-07-31

Last updated by the study team

2025-09-04

Who can join

Age: 12 and older, up to 20. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Turner Syndrome and Primary Ovarian Insufficiency.
• Prescribed adult dosing* of transdermal or oral estradiol for estrogen replacement therapy.
• Adult dosing of will be defined per published clinical practice guidelines from the 2023 International Turner Syndrome Meeting (i.e. 50-200μg/day of transdermal estradiol, or (i.e. 50-200μg/day of transdermal estradiol or 2-4mg/day oral estradiol).
• Have achieved menarche.

You may not qualify if…

• Disclosure of sexual activity and desire for contraception.
• Having a levonorgestrel-releasing intrauterine device or etonogestrel arm implant in place.
• Having received depot medroxyprogesterone within one year prior to study recruitment.
• Non-English or non-Spanish speaking.

Where it is running

• Children's Mercy Hospital — Kansas City, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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