Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum Depression

Recruiting now · Phase 4

Conditions studied: Postpartum Depression (PPD)

In brief

The objectif of the IRON-DEP Study is to assess the efficacy of intravenous (IV) versus oral iron treatment on the prevalence of postpartum depression (PPD) in women with moderate iron deficiency anemia after caesarean delivery.

Key facts

Study ID

NCT06833788

Run by

Assistance Publique - Hôpitaux de Paris

People needed

2860

Starts

2025-10-22

Expected to finish

2028-10-30

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Ferritinemia ≤ 100 ng/mL OR transferrin saturation ≤ 20% measured after postoperative Hb level measurement
• EPDS score in the immediate postpartum <11 with a "never" answer to question n°10

You may not qualify if…

• Stillbirth or neonatal death
• Last body weight available before inclusion (measured at the end of pregnancy or in postpartum) < 35kg or > 100kg
• Biermer disease
• Hemochromatosis
• Homozygous sickle cell disease or thalassemia
• Chronic iron supplementation (outside pregnancy)
• Known hypersensitivity or allergy to the studied drugs (IV or oral iron)
• Contra-indication to the studied drugs (IV or oral iron)
• Severe asthma (with daily background treatment)
• Any known severe renal or liver disorder
• Active acute infection
• Diagnosis of schizophrenia or physical and intellectual state incompatible with a reliable self-evaluation
• Women currently treated with medication or with Electro Convulsion Therapy (ECT) for depression or bipolar disorders
• Participation in another clinical trial involving an intervention with the following risks:
• A change (increase or decrease in value) in Haemoglobin measured at 2 months postpartum OR
• A change in EPDS score measured at 2 and 6 months postpartum OR
• A trial exploring an intervention with a specific anaphylactic risk (reported as a potential adverse events in the protocol of the other trial) administered during the postpartum hospitalization period.
• Poor understanding of the French language
• Legal protection (curatorship or tutorship)

Where it is running

• CHU Armand -Trousseau, AP-HP Service d'anesthésie-réanimation chirurgicale — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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