Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma

Recruiting now · Not applicable

Conditions studied: Neuroblastoma, High-risk Neuroblastoma

In brief

The goal of this study is to test if the addition of a novel income-poverty targeted supportive care intervention (Pediatric Resource Intervention to Support Equity \[Pediatric RISE\]) to usual supportive care for low-income children with high-risk neuroblastoma can improve parent- and child-centered outcomes. Participants will be randomized to receive one of the following for 6-months: * Usual supportive care alone or * Usual supportive care plus Pediatric RISE

Key facts

Study ID: NCT06831552
Run by: Dana-Farber Cancer Institute
People needed: 84
Starts: 2025-04-30
Expected to finish: 2029-06-01
Last updated by the study team: 2026-02-10

Who can join

Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patient cohort: The randomized Phase II multi-center RISE intervention will be conducted among a population of poverty-exposed children with high-risk neuroblastoma. Poverty will be a priori defined as parent-reported low-income (<200% Federal Poverty Level). Children receiving treatment for cancer at study sites will serve as the study cohort, with parents/guardians as survey informants and intervention recipients on behalf of their minor children given that parents (not children) typically manage household finances.
Patient newly diagnosed with high-risk neuroblastoma
Patient has established care at study site and initiated cancer-directed therapy
Patient has not yet initiated Induction Cycle 3
Patient aged 0-17 years at the time of consent
Parent/guardian screened positive for self-reported low-income (<200% Federal Poverty) *
Family primary residence in MA, PA, IL, CA, WA, CT, GA, WI and OH
Both patients co-enrolled on ANBL2131 or those receiving standard of care therapy at their center are eligible to participate
Patients of all languages are eligible to participate

You may not qualify if…

Foreign national family receiving care as an Embassy-pay patient.
Child or household member receiving SSI

Where it is running

Connecticut Children's Medical Center — Hartford, Connecticut, United States (enrolling)
Children's Healthcare of Atlanta — Atlanta, Georgia, United States (enrolling)
Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
University of Texas Southwestern Medical Center — Dallas, Texas, United States (enrolling)
Seattle Children's Hospital — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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