Elective Adaptive Radiation With SBRT for Improved DurabilitY of Response
Recruiting now · Not applicable
Conditions studied: Prostate Adenocarcinoma, Iliac Nodal Disease, Para-aortic Lymph Node Metastasis, Para-aortic Nodal Disease, Oligorecurrence
In brief
This prospective, single-arm feasibility study will include patients with prostate cancer that have controlled local disease diagnosed with oligorecurrent para-aortic nodal disease and/or common iliac nodal disease detected by PSMA PET or conventional CT/MRI imaging, and these patients will undergo CT-guided online adaptive SBRT to the tumor and elective SBRT to adjacent at-risk nodal regions.
Key facts
- Study ID
- NCT06831032
- Run by
- University Health Network, Toronto
- People needed
- 26
- Starts
- 2026-07-07
- Expected to finish
- 2029-07-07
- Last updated by the study team
- 2026-03-23
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed prostate adenocarcinoma.
- Oligorecurrent para-aortic +/- common iliac nodal disease planned for SBRT.
- ≤10 involved para-aortic (defined as between L1/L2 interface and L4/L5 interface) +/- common iliac LN on PSMA PET imaging.
- ECOG performance status 0-2.
You may not qualify if…
- Prior radiotherapy to the nodal echelon (PA +/- common iliac).
- Active secondary malignancy, except for adequately treated non-melanoma skin cancer.
- Presence of significant comorbidities or medical conditions that may compromise the ability to undergo radiotherapy or participate in the study.
- Contraindication to radiation.
Where it is running
- Princess Margaret Cancer Centre — Toronto, Ontario, Canada (enrolling)
Full record on ClinicalTrials.gov
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