Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH

Completed · Not applicable · Has a placebo group

Conditions studied: Methamphetamine Use Disorders, HIV

In brief

The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.

Key facts

Study ID

NCT06830980

Run by

Gopalkumar Rakesh

People needed

12

Starts

2025-03-11

Expected to finish

2026-05-26

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults in the age group 18-65 years
• Able to read and understand English
• Able to provide informed consent
• Diagnosed with HIV
• History of current or previous Methamphetamine Use Disorder
• Endorse craving for methamphetamine
• Demonstrate an attentional bias for methamphetamine

You may not qualify if…

• Traumatic brain injury
• h/o seizure disorder
• h/o or current diagnosis of schizophrenia
• intracranial metal shrapnel
• previous adverse effects with TMS
• sub-threshold consistency while performing behavioral tasks
• lack of attentional bias to methamphetamine cues
• a positive pregnancy test for female participants
• abnormal brain MRI

Where it is running

• UK Department of Psychiatry — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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