Nasal Obstruction With Oxymetazoline and Corticosteroids

Recruiting now · Phase 2

Conditions studied: Nasal Obstruction

In brief

This study aims to examine the efficacy and safety of commination oxymetazoline/intranasal steroids for long-term management of chronic nasal obstruction that is recalcitrant to the current standard of care. The investigators hypothesize that combination treatment with oxymetazoline and intranasal corticosteroid spray will provide a larger reduction in nasal obstruction than intranasal corticosteroid alone for patients suffering from chronic nasal obstruction, and there will not be occurrences of rhinitis medicamentosa.

Key facts

Study ID: NCT06830109
Run by: Washington University School of Medicine
People needed: 80
Starts: 2024-10-15
Expected to finish: 2026-12-30
Last updated by the study team: 2025-09-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

males and females ages 18 years or older
have a history of nasal obstruction
have failed a trial of topical steroids (that included at least 1 month of daily use)
ability to read, write, and understand English
either do not desire surgery or are poor surgical candidates due to medical comorbidities.
Patients who have had prior use of oxymetazoline or other nasal decongestants are eligible for the study but must have stopped usage 4 weeks prior to randomization.
Must be willing to stop using any other nasal sprays, besides saline, and oral decongestants.

You may not qualify if…

Any history of sinonasal mass/tumor
Any history of nasal polyps
a known history of chronic sinusitis
an allergy to oxymetazoline
or who have any medical contraindication to oxymetazoline use, such as pulmonary hypertension.

Where it is running

Washington University — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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