Local or Systemic Effects: Mechanisms Related to Arm Crank Exercise - Comparison Between Individuals With and Without PAD
Enrolling by invitation · Not applicable
Conditions studied: Peripheral Arterial Disease
In brief
INTRODUCTION: Exercise with an arm ergometer (EB) overcomes the main barrier to physical exercise in patients with Peripheral Artery Disease (PAD), leg pain during walking. Due to its aerobic nature, this type of exercise can cause systemic changes in the regulatory mechanisms of vasodilation. In other words, it provides vascular benefits in the most affected arterial beds in the PAD population. OBJECTIVE: To analyze local and systemic vascular responses, as well as cell signaling pathways after an EB exercise session in patients with PAD and their peers without PAD. METHODS: 24 patients with PAD and 24 individuals without PAD will be recruited, matched by sex and age. Participants will undergo two experimental sessions in approved order (EB and control). The EB session will consist of 15 cycles of 2 min of exercise with an intensity equivalent to 13-15 on the Borg scale of perceived exertion. Before and after the experimental sessions, the vascular function of the brachial and femoral arteries, blood indicators of vasodilation and calf muscle oxygenation will be evaluated. To analyze the acute effect between groups on cardiovascular parameters, a three-way analysis of variance will be performed, taking as factors disease (presence vs. absence), session (EB vs. Control) and time (pre vs. post). In all analyses, when a significant effect is selected, the Bonferroni or Newman-Keuls post-hoc test will be used. For all analyses, a value of P\<0.05 will be considered significant.
Key facts
- Study ID
- NCT06828172
- Run by
- University of Nove de Julho
- People needed
- 24
- Starts
- 2025-03-24
- Expected to finish
- 2027-07-15
- Last updated by the study team
- 2026-04-13
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- If female, must be postmenopausal without hormone replacement therapy;
- Non-smokers;
- With a body mass index (BMI) not exceeding 30 kg/m²;
- With calf skinfold thickness below 20 mm, due to the interference of adiposity in the penetration of light from the NIRS probe, and oxygen saturation in the finger >95% to ensure that impaired pulmonary gas exchange does not affect oxygen saturation measurements in the calf;
- Not using classic antioxidants or vitamin supplements; and
- Physically capable of performing an exercise session.
- For the group of participants with PAD, in addition to the criteria mentioned above, they must have a confirmed diagnosis of the disease, characterized by an ankle-brachial index (ABI) lower than 0.90 in one or both legs, exhibit symptoms of claudication during walking, and be physically capable of performing an exercise session to participate in the project.
You may not qualify if…
- Only participants who discontinue their participation in the study protocol will be excluded from the sample
Where it is running
- University Nove de Julho — São Paulo, São Paulo, Brazil
Full record on ClinicalTrials.gov
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