Evaluating Q-Collar Effects on Brain Blood Flow Control During Exercise

Recruiting now · Not applicable

Conditions studied: Healthy

In brief

The goal of this clinical trial is to learn how the FDA-cleared Q-Collar device affects brain blood flow regulation during rest and exercise in healthy adults. The main questions this study aims to answer are: 1. How does the Q-Collar affect brain blood flow when there are quick changes in blood pressure, like when standing up quickly, or when breathing against resistance? 2. How does the Q-Collar affect brain blood flow during exercise? Researchers will compare sessions where participants wear the Q-Collar to sessions where they do not wear the device to see if the Q-Collar improves brain blood flow during both rest and exercise. Participants will: * Complete two study visits, each 1 to 4 weeks apart. * Perform a series of tasks, including standing tests, breathing tests, and exercise on a stationary bike, while their heart rate, brain blood flow, and other body functions are monitored. * Wear the Q-Collar during one of the sessions and not wear it during the other session. The order of the sessions will be randomly assigned.

Key facts

Study ID

NCT06826781

Run by

Spaulding Rehabilitation Hospital

People needed

20

Starts

2025-07-23

Expected to finish

2026-08-23

Last updated by the study team

2025-10-27

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy individuals between the ages of 18 to 30 years old

You may not qualify if…

• History of concussion or other brain injury resulting in loss or alteration in consciousness or other change in cognition within 24 months of study visit
• High cardiac risk according to the American College of Sports Medicine (ACSM)11
• Ongoing active treatment with a cardioactive drug
• Inability to stand from a seated position unassisted
• History of a neurologic disorder or neurosurgery intervention
• Pregnancy
• Any current, serious, chronic medical or psychiatric disease that in the Principal Investigator's or co-investigator's judgment may interfere with study participation or data integrity
• Unable or unwilling to provide informed consent

Where it is running

• Spaulding Rehabilitation Hospital — Cambridge, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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